Blade Runner is an absolute masterpiece, and has without any doubt a genial touch. I don't think you have to be a melancholic to see that clear, it might help though. BR is a philosophical statement about whom we are, about life and death. It does indeed not give any answers as prognose our future, but it surely defines our humanity as we have known it untill now.
But above all, it's an esthaetic, no not anaesthetic, masterpiece in cinema, like a Rembrandt to painting, a soundscape unheard before, with all the elements of pure sensuality, as in dreams or sometimes nightmares.
Watching the movie is a dream, an evasion, and makes us accept better what we are : temporary humans...
Brilliant !