Handshakes can be handed out like hellos or they can be seen as an act of sealing a contract between two people, they can be no big deal or they can be an intimate exchange of skin cells and body heat.
It's really up to the person involved in the handshake to decide whether it's a nod or a bond, intimate or totally devoid of feeling, but when the shaker finds the act to be a bit too intimate they may feel like they're stuck in a sticky situation.
Handshake is a shaky animated short by Patrick Smith that has an eye-pleasing comic strip feel and a silly storyline that seems like a nightmare a germophobe or introvert would have.