Some people can be happy anywhere, but there's no denying that where you live can certainly make a difference in how happy you are. Wallethub recently calculated the relative happiness of people in each state based on three main metrics: how emotionallly and physically well people are there, the quality of the local career options and their community and environmental appeal.
Based on these qualifications, Minnesota, Utah, Hawaii, California and Nebraska are the five happiest, while West Virginia, Oklahoma, Louisiana, Alabama and Arkansas are the least happy. You can see the rankings of all the states in between here.
Via Newser
https://www.cdc.gov/drugoverdose/data/prescribing.html
Especially for Virginia vs. West Virginia. (Sorry, Virginias!)
Whether the happiness map is showing people who are unhappy because they live in the Bible Belt as fulgora77 points out or if it's simply a map of where they think people should be happy as Edward suggests, taken generally this seems to suggest a relationship between the thoughts "life sucks" and "give me the drugs that make me not care about things being painful."