Artist Bryan Lewis Sanders wondered how different drugs may affect his perception, so he started a series where he did self portraits under the influence of (or shortly after doing) different drugs. At first he did the experiment once every day, but after a few weeks, he started suffering from lethargy and mild brain damage. While he's continuing the experiments to this day, now he's limiting himself to occasional drugs administered under the expertise of medical professionals.
While his artworks don't always portray how the drug makes a person feel while they are using them, they do illustrate how the artist feels while on the drug or at least while thinking about the drug. For example, the top image demonstrates Ambien, the middle one PCP and the one below on hash.
Needless to say, even if you do enjoy occasional recreational drug use, this is an experiment you really shouldn't try at home.
Via RYOT