The Japanese design firm nendo and the electronics company Elecom came up with this innovative mouse design. The Kandenchi has three buttons and a scroll wheel. It connects to a computer through a wireless hookup.
Link (Google Translate) -via OhGizmo!
Like many things using a mouse should become second nature after a while. You don't think about walking and you shouldn't need to think about using a mouse.
It's kind of like driving different cars, even when driving a totally new car I don't need to think about gear selection. It just happens because I'm so used to driving.