DeviantArt user *TsaoShin re-created the image Michelangelo's "The Creation of Adam" from the Sistine Chapel with Mario. Playing the role of God is Shigeru Miyamoto, who created the lovable plumber and named him after a landlord who barged in on Nintendo's company meeting demanding an overdue rent.
Link: *TsaoShin's DeviantArt page | 10 Mario Fun Facts | Mario Infographics
See also: Mario-related posts over at NeatoGeek
http://twitpic.com/1t9kvq