Last summer David Byrne of The Talking Heads converted an entire building, the Camden Roundhouse in London, into a musical instrument! He connected every pipe, pillar, and beam to a keyboard, from which you can make them vibrate and produce their individual sounds. This is one only of several large and different musical instruments made out of structures such as silos, a tower, a synagogue, and more at Dark Roasted Blend.
Link(Image credit: Mark Obstfeld)