Within a storytelling construct, an antagonist is key, and cartoons have had some of the most dynamic, interesting villains throughout history. The list at Bezbrige has ten interesting choices, including everybody's favorite desert dog: Wile E. Coyote.
See the rest of the list, and come back and tell us what they missed.
Link. Cartoon still from Fast & Furryous, 1949. (Wikimedia).
Wile Ethelbert Coyote seems to have an endless supply of Acme tools that he can use against the innocent Roadrunner. In every episode he attempts to destroy the Roadrunner with a bag of tricks that would make any terrorist envious. Thankfully he usually fails and blows himself up (something else the terrorists are probably familiar with).
See the rest of the list, and come back and tell us what they missed.
Link. Cartoon still from Fast & Furryous, 1949. (Wikimedia).
He was pretty much entirely incompetent but he stole the Eiffel tower and burned all the cash in the USA.