(Video Link)
Graffiti artist Tony Quan suffers from amyotrophic lateral sclerosis (Lou Gehrig's Disease) and is unable to move any part of his body other than his eyes. But thanks to an open source computer project called EyeWriter, he can still draw. The technology tracks the movements of his eyes, allows him to select different shapes and colors, and then projects his images onto the sides of buildings. The above video is a selection from a documentary about the project.
Link via Gizmodo
The Eyewriter is awesome and open sourcing is kick ass!
Incidentally, the two people I know who died of the disease were both around paint quite a bit, one being a painting contractor and the other a residential landlord.
:'(