In terms of overall animal health, Weindruch notes, the restricted diet leads to longer lifespan and improved quality of life in old age. "There is a major effect of caloric restriction in increasing survival if you look at deaths due to the diseases of aging," he says.
The incidence of cancerous tumors and cardiovascular disease in animals on a restricted diet was less than half that seen in animals permitted to eat freely. Remarkably, while diabetes or impaired glucose regulation is common in monkeys that can eat all they want, it has yet to be observed in any animal on a restricted diet. "So far, we've seen the complete prevention of diabetes," says Weindruch.
From the Upcoming ueue, submitted by coconutnut.
One thing that advocates of calorie restricted diets DON'T tell you is that these monkeys, although healthy and have longer lifespan, are actually meaner (especially when it comes to food). They're constantly hungry and thus will fight for food.
http://junkfoodscience.blogspot.com/2009/07/calorie-restrictive-eating-for-longer.html
An excerpt from an article in The New York Times quoted in the above article:
"If caloric restriction can delay aging, then there should have been significantly fewer deaths in the dieting group of monkeys than in the normally fed comparison group. But this is not the case. Though a smaller number of dieting monkeys have died, the difference is not statistically significant, the Wisconsin team reports."
I'm guessing this has something to do with our evolution when food was scarce. Low calorie intake was the norm, all this extra stuff we're jamming into ourselves is making us sick. No surprise there. The mediterranean diet also has health and longevity benefits but you get to have wine and food that actually tastes good. I'd be mean if I was hungry all the time. You become obsessed with food. Ask anyone on a strict diet. Anorexics become chefs pretty often.
http://junkfoodscience.blogspot.com/2009/07/calorie-restrictive-eating -for-longer.html
How to apply that to individual humans is the issue. My suggestion is that if you want to live as long as possible (a goal to which I do not aspire), you exercise every morning until you breathe hard and sweat (but no longer), force yourself to skip one meal every two days even though you are hungry, never take alcohol, tobacco or other recreational drugs, engage in vigorous and frequent sex (getting sweaty and out of breath is allowed), get eight hours of sleep every night and brush your teeth after every meal.
Of course for this study, it's not that I would live longer, just that it would feel like it.
That junkfoodscience article uses several flawed premises - she complains about monkeys being disqualified, and alleges that the study authors committed scientific fraud by omitting deaths - if the monkeys died because they bit each other fighting, then they should be disqualified from the test. That death had no bearing on whether they were on caloric restriction or not, and should be discarded under good study management. The woman at that blog makes her name by being smug and sniping at other peoples studies, so her motives are suspect.
Another point is that they did plain "caloric restriction" - in other words starving the monkeys with no effort to make up the vitamin and mineral deficit wrought by the diet. The right way for people to do CR is to do CRON - caloric restriction with optimal nutrition which makes sure every bit of the RDA is taken in every day with low calorie, nutrient dense foods. If her analysis of the study is correct (which I doubt), the study was not done well, which explains the null results. There are hundreds of other studies with all sorts of animals that show a clear increase in longevity not only for CR, but especially for CRON diets.
Also, Re:
"If caloric restriction can delay aging, then there should have been significantly fewer deaths in the dieting group of monkeys than in the normally fed comparison group. But this is not the case. Though a smaller number of dieting monkeys have died, the difference is not statistically significant, the Wisconsin team reports."
That doesn't specifically disprove the theory behind CR. It means the study was null and we can't draw any conclusions from it. However, they _did_ see qualitative effects that were interesting and probably should be investigated further.
It's hardly junk science...just junk reporting.
This doesn't sound appealing at all.
Resveratrol is supposed to make you live longer, too. Ashkenazi Jews have a mutation that make them live longer, healthier lives under the right circumstances. That's my problem with life extending research. My 90 year old ashkenazi grandmother who is in perfect health aside from Alzheimer's. I know I don't want to live that long when I haven't seen a single suggestion of preserved cognitive functioning to go along with that old age. 110 and counting with dementia? No, thanks. People on CR must be betting on a cure within their lifetime. There's something to be said for advancing one part and expecting the other to catch up, I'm just not an optimist. (I am, however, verbose)
As I suspected, Ms. Szwarc (junkscience) writes for a lobbying firm that denies global
warming, etc and is funded by McDonalds, among other conglomerates. (If you
know who is paying for an opinion, you can generally figure out what it will
be.)
http://www.sourcewatch.org/index.php?title=Tech_Central_Station
She is identified here as an "obesity crank" and for misinterpreting studies
and other sophistry here:
http://scienceblogs.com/denialism/2007/12/obesity_crankery_a_growing_pro.php
#more
http://www.sourcewatch.org/index.php?title=Sandy_Szwarc
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